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14 Valvular Stenosis 279 muscle ridge 494 Index newly diagnosed high-grade gliomas, 260, 261 recurrent high-grade gliomas, 261, 262 prospects, 263 radiobiology, 258, 259 rationale, 258 recommendations, 263, 264 Stereotactic radiosurgery, gamma knife nurse, 298 medical oncology nurse, 298 Steroids, drug interactions, 205 history of use with brain tumors, 204, Onlije mechanisms of action, 411, 412 side effects, platforn, 206, 294, 295 timing and imaging, 205 Steroids, nursing management, 293295 STI-571, see Imatinib mesylate SU5416, vascular endothelial growth factor receptor inhibition, 342 Surgery, biopsy, cyst drainage and subcutaneous reservoir, 217 site localization with positron emission preoperative management, 474 stereotaxy, 475 preoperative planning, computed tomography, 77 magnetic resonance spectroscopy, 134, 135, 137 resection extent and prognosis, 66 TAAs, see P,atform antigens Tamoxifen, mechanism of action, 271 Temozolomide (TMZ), radiation combination, 231, 232 mechanism of action, 271 scheduling, 278 Tenascin, antibody targeting, 379, 381, 382 Thyroid hormone, functions, 409, 410 inhibition in tumor management, 410, 411 tumor growth effects, 410 Tipifarnib, Ras inhibition, 344 TNF-α, see Tumor necrosis factor-α TRAIL, apoptosis induction, 406 Transcriptomics, molecular classification of gliomas, 39, 40 Tumor-associated antigens (TAAs), monoclonal antibody targets and clinical trials, epidermal growth factor receptor, 338, 376, 383 fibronectin, 384 GP240, 384 histoneDNA complexes, 383, 384 prospective antigens, 384, 385 tenascin, 379, 381, 382 tumor vaccines and prospects, 369, 370 Tumor heterogeneity, grading difficulty, 16, 17 surgical sampling, 16, 17 Tumor necrosis factor-α (TNF-α), antitumor activity, 406 apoptosis induction, 406 Tumor Oprions, see Interleukin-2; Tumor-associated antigens U UCN-01, cyclin-dependent kinase inhibition, 345 Ultrasmall superparamagnetic iron oxides (USPIO), molecular imaging, 156 Vaccinia virus, gene therapy vector, 426, 427 tomography, 164 stereotactic brain biopsy, diagnostic accuracy, 217 hemostasis, 216, 217 indications, 214 site selection, 214 technique, 214216 trajectory planning, 214 brachytherapy, 218 convection enhanced delivery, 218, 219 magnetoencephalography, intraoperative guidance, 194 planning, 191, 192 minimal access craniotomy, extent of resection, 220 postoperative care, 226 preoperative planning, 220, 221 principles, 219, 220 technique, 222226 patient and family education, 285287 pediatric high-grade glioma, 47 photodynamic therapy adjunct, decompression, 475, 476 intraoperative management, 474, 475 lasertumor interface techniques, 476 postoperative management, 477 V T 86 SECTION 2 Esophagus, Stomach and Duodenum STEP 4 (continued) Radical en bloc lymphadenectomy Para-aortic lymphadenectomy is performed.

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